Flores started her career in the early 1970s and with the release of the album Amor, amor (and a single of the same name) in 1975 she achieved success in her native Spain as well as in countries in Latin-America.

Her songs "Sarandonga", "Lo voy a dividir", and "Si la vida son dos días" among others, have become staples in Spanish radio.

In 2002, she won a Goya Award for Best New Actress for her performance in the movie Rencor.

Flores has also appeared in several television programs such as Directísimo and Hostal Royal Manzanares.

On 18 February 2019 she received the Medalla de Oro al Mérito en las Bellas Artes.