Her brother, Napoleon Brown, is in prison serving a 44-year sentence for a 2000 conviction on charges of manslaughter and armed robbery, for which Breed has repeatedly asked for clemency from the governor's office.

[17] During her first few months as Supervisor in 2013, Breed persuaded city departments to complete two new bike lanes on Oak and Fell Streets ahead of schedule, prompting the local transportation site StreetsblogSF to say she had “emerged as a bicycling champion.”[18] She secured federal funding for the redesign of Masonic Boulevard in her district,[19][20] which added bike lanes and traffic safety measures to one of the most dangerous corridors in the city.

[26][27] Breed cosponsored 2014's Proposition A, a $500 million bond to fund street repaving, infrastructure repair, transit service improvements, and increased bicycle and pedestrian safety.

[34] When the federal Department of Housing and Urban Development threatened to block the legislation, she flew to Washington, D.C., with a delegation of San Francisco officials and persuaded it to let the program proceed.

Breed was outspoken in demanding improvements, pushing then-Mayor Lee to do more, expressing a lack of confidence in Fire Chief Joanne Hayes-White,[45] and generating press attention for the issue.

[46] Breed fought for substantially more funding for emergency medical services,[47] ultimately succeeding in getting $47.3 million invested to hire EMTs, paramedics, firefighters, and 911 dispatchers, as well as buy new ambulances and fire trucks, and improve SFFD facilities.

[55] As part of an FBI investigation into public corruption and bid-fixing primarily involving then-State Senator Leland Yee,[56] businessman Derf Butler was recorded talking about allegedly paying for access to Breed.

According to court documents released in 2015, Butler told an FBI source that he "pays Supervisor Breed with untraceable debit cards for clothing and trips in exchange for advantages on contracts in San Francisco."

[82] In March 2019, Breed awarded a posthumous certificate of honor to Sinn Féin politician and former IRA member Martin McGuinness for his "courageous service in the military".

[87] In December 2020, Governor Gavin Newsom announced that Alex Padilla would succeed Kamala Harris as U.S. senator after she was elected to serve as Vice President of the United States.

[5] On February 25, 2021, Breed announced the "Dream Keeper" initiative to invest $120 million dollars from former law enforcement budgets into revitalization of San Francisco's black community.

[97] After the 90-day State of Emergency concluded, ABC7 reported that significant progress had been made in the area, stating that “Eleven-thousand grams of fentanyl have been seized and ten percent of drug users who have come to get help have agreed to some kind of treatment or medical care.”[98] In late 2023, Breed announced the creation of a new Joint Task Force with SFPD, the San Francisco District Attorney’s Office, the California Highway Patrol, and the California National Guard in order to combat the opioid epidemic.

[103] This proposition authorized the San Francisco Police Department to utilize drones instead of or in addition to car chases, and allowed SFPD officers to engage in more efficient reporting practices.

[104] On August, 29th, 2024, the City reported that auto break-ins dropped 57% compared to the same period in 2023, thanks in part to the use of drones, automated license plate readers, and bait operations.

[110] This was to be accomplished by converting office buildings to residential and commercial, constructing new student housing, and working with state leaders to create incentives for businesses to move to or remain in San Francisco's downtown.

Breed sponsored Proposition C in San Francisco's March, 2024 primary election, which gives a transfer tax exemption the first time commercial properties are converted into residential uses.

[115] On September 26, 2024, Mayor Breed and Supervisor Matt Dorsey (who represents much of Downtown and the Financial District) proposed legislation which would eliminate office to housing conversion fees.

[120] This plan includes increasing density along certain corridors in San Francisco's western neighborhoods, such as the Sunset, Richmond, and Lakeside, which are predominantly made up of single family homes.

[134] Breed worked with the San Francisco Municipal Transportation Agency and Bay Area Rapid Transit and carried the legislation[135] to add cellular service for riders on Muni's underground trains.

[145] Breed’s SFMTA also established the Slow Streets Program in 2020 in order to create a network of “safe, comfortable, low-vehicle-traffic routes” throughout San Francisco, to facilitate active modes of transportation such as biking and walking.

[152] To help achieve this goal, she introduced legislation declaring a shelter crisis in San Francisco,[153] which allows the city to waive certain permitting and contracting requirements for homeless services.

Breed and other California politicians such as Governor Gavin Newsom and San Jose Mayor Sam Liccardo were criticized for not following the same public health guidelines they administered.

"[168] A series of 2018 reports in the San Francisco Examiner focused on Breed's use of campaign funds carried over from previous years to pay for floats in San Francisco's annual Pride parade, and a 2020 report found that Nick Bovis, a restaurant owner arrested alongside Mohammed Nuru, was solely named on an invoice to pay for Breed's 2015 Pride float, when she was a member of the Board of Supervisors.

A 2020 report in the San Francisco Chronicle found that the woman identified as "Girlfriend 1" by federal officials in the criminal complaint filed against Nuru was Sandra Zuniga, former Director of the city's "Fix-It Team" and of the Office of Neighborhood Services.

According to the San Francisco Department of the Environment's Climate Action Strategy: "Moving to 100% renewable electricity is the single biggest step the City can take to reduce GHG [Greenhouse Gas] emissions.

"[176] When Breed took office in 2013 CleanPowerSF had, according to the San Francisco League of Conservation Voters, "languished for 12 years" in the face of opposition from multiple mayoral administrations, the city's utility provider PG&E, and other business interests.

[183] In the summer of 2015, the International Brotherhood of Electrical Workers Local Union 1245, which represents PG&E employees, submitted a ballot measure, Proposition G, that would have imposed restrictions on CleanPowerSF.

The San Francisco Chronicle wrote, "The award for most creative campaign ad goes to Board of Supervisors President London Breed..[It] is akin to an ingenious high school video production.

[201] This prompted Breed's then-Chief of Staff Conor Johnston to write a scathing article in the San Francisco Examiner accusing the local Sierra Club chapter of hypocrisy and "bewildering anti-environmentalism" for blocking new housing and engaging in "political tribalism".

[210] In February 2020, Breed made the Nob Hill Gazette's ranking of "A-List Eligibles," listing single celebrities who are notable in San Francisco.