Running between Clapham Park and St Bartholomew's Hospital, it is operated by Arriva London.

The move, which was intended to provide a direct link between Waterloo and St Pancras stations, coincided with the relocation of the Eurostar terminal.

[3] On 20 December 2013, thirty people were injured when the driver of a route 59 bus swerved to avoid a vehicle and hit a tree in Kennington.

[8][9] On 23 November 2022, it was announced that route 59 would be rerouted to run to St Bartholomew's Hospital instead of Euston following a consultation.

[10][11] In September 2024, Transport for London launched a consultation proposing to modify the route to terminate at Clapham Park instead of Streatham Hill to replace route 45.