The London Midland Region (LMR) was one of the six regions created on the formation of the nationalised British Railways (BR), and initially consisted of ex-London, Midland and Scottish Railway (LMS) lines in England, Wales and Northern Ireland.

The region was managed first from buildings adjacent to Euston station, and later from Stanier House in Birmingham.

The LMR initially continued building ex-LMS stock, particularly Black Fives, Ivatt 2MT, two Duchesses, and rebuilds of Royal Scots and Patriots.

Stanier "Period III" carriages continued to be built and were developed into a new style known as "Porthole" stock.

In the 1960s, the West Coast Main Line was electrified between London Euston and Crewe, Liverpool, Manchester and Birmingham.