She had a brief interlude as Chief Operating Officer (COO) for the Bikuben Foundation, before becoming Head of the Department of Security Policy at the Ministry of Foreign Affairs from 2007 to 2009.

During her time as ambassador, Wisborg advocated for e.g. increased agricultural support for impoverished Spanish regions at EU-level, modernization of the European Union, ⁣renewable energy transition and environmental awareness.

[15][16][17] In the aftermath of this diplomatic tension, the Prime Minister's Office and the Ministry of Foreign Affairs took efforts to ease the situation.

The Ministry of Foreign Affairs and the Danish embassy in Washington engaged their diplomatic connections with top government officials in the United States.

Having landed in Copenhagen Airport to attend the annual Ambassador's Meeting, she promptly returned to her office and staff in Washington in an endeavour to de-escalate the situation.

The correspondence on mutual defence policies resulted in Denmark committing to send an additional 500 soldiers to international missions in September 2019, as well as taking over responsibility from Canada for NATO's training mission for Iraqi soldiers[25] In October 2019, she, together with the four other Nordic US ambassadors, Bergdis Ellertsdottir (Iceland), Karin Olufsdotter (Sweden), Kirsti Kauppi (Finland) and Kåre R. Aas [no] (Norway), formed a unified Nordic front, advocating for climate change action in Washington, highlighting Scandinavian solutions and initiatives.

[28] She served in this position until 2025, when she became self-employed and started the firm Wisborg Advisory to advise companies on geopolitical challenges.