Lone Mathiesen (born 28 January 1972) is a former Danish handball player and World champion.

She has a few times during injury crises helped her old club Skovbakken.

Most prominently in SK Aarhus' 2010 Cup final against FCK Håndbold.

Lone Mathiesen is the mother of the current Danish handball player Julie Scaglione.

This biographical article related to Danish team handball is a stub.