[2] Membership remained unchanged until the conference announced on June 18, 2007, that it had invited three private universities—Gannon University and Mercyhurst College in Erie, Pennsylvania and C.W.

[3] Gannon and Mercyhurst left the Great Lakes Intercollegiate Athletic Conference to join the PSAC, effective July 1, 2008.

[7] The arrival of these two schools brought the PSAC to 18 full members, making it the largest NCAA all-sports conference in terms of membership at that time.

[a][b] In March 2018, charter member Cheyney University of Pennsylvania, facing crises in enrollment, graduation rates, and finances, announced that it would leave NCAA Division II and the PSAC at the end of the 2017–18 school year.

[10] As of April 4, 2024, Mercyhurst announced that it will leave the PSAC to transition to NCAA Division I and join the Northeast Conference, beginning the 2024–25 academic year.

[11] The PSAC played a little-known but nonetheless significant role in the history of NCAA Division I conference realignment.

Then-conference commissioner Tod Eberle asked Dick Yoder, then athletic director at West Chester and member of the Division II council, to draft NCAA legislation that would allow the PSAC to play a conference title game that would be exempt from regular-season limits.

[12] Before Yoder formally introduced the proposal, he was approached by the Central Intercollegiate Athletic Association, which was interested in co-sponsoring the legislation because it was also split into football divisions and wanted the option of a championship game.

In 2014, then-Sports Illustrated writer Andy Staples said that the rule "helped dictate the terms of conference realignment for more than 20 years.