In August 2000, it opened its first banking center outside of Hidalgo County in Rio Grande City, Texas.

The bank's first office outside of the Rio Grande Valley was opened in Bexar County in San Antonio in early 2010 with three more centers added; one in 2011 and two in 2013.

[5] An additional consent order (2015-029)[6] was issued on March 31, 2015, in regards to serious deficiencies in Lone Star National Bank's lending practices.

Each December, Lone Star National Bank hosts an annual toy drive for children in the Rio Grande Valley and San Antonio.

The bank's multiple locations decorate Christmas boxes to generate interest and curiosity for the drive.

The bank invites all residents of the Rio Grande Valley to visit its locations to drop off unwrapped toys of various types.