A remake of the game, titled Super Lone Survivor released for Nintendo Switch and Microsoft Windows on October 31, 2022.

[3] Lone Survivor is a post-apocalyptic survival horror game with retro-styled 2D graphics in which the player controls a nameless protagonist following directions provided by the character's apparent hallucinations.

Failing to locate these items can result in resources being spent without new areas being opened up, making future attempts more difficult.

This character is an isolated survivor of an infection which has turned his city's (and possibly the world's) population into aggressive, shambling mutants.

With limited food and an increasingly fragile mental state, the player character must be guided outside his apartment to scavenge and explore.

[4] Time progresses, in the form of days, as the player saves, by the means of sleeping in the man's apartment (and experiencing strange dreams or hallucinations, by taking either blue or green pills), which appears to be the safest area in the entire game.

A nameless man in a surgical mask (referred to in the game as "You") has been living in an apartment for an unspecified amount of time after a disease has turned most of the city's inhabitants into mindless zombie-like monsters.

At the end of this dream, a man wearing blue with a single gunshot wound appears before the survivor wakes up.

Following leads picked up from his radio, annotated maps, and discarded diary entries, the man explores the apartment complex infested with monsters.

Seeing nothing else to do, he takes a blue, red or green pill (depending on how the player progressed through the game) at the bedside and then goes to sleep.

In the Director's Cut, assuming the player has the maximum mental health score, and does a multitude of other things throughout the game, they will get a different ending, where the character walks down a hallway in the hospital while hiding from the girl in the blue dress, who appears to be infected and is crawling across the ground.

In the 'green' ending, it is suggested through cryptic and brief flashbacks of conversations that the woman in blue was a sister, spouse, or girlfriend to the man and that she had possibly died in some form of accident or illness (although it is implied that it could be the result of a car bomb, judging by the deprived environment in the city and several references to war within the game).

By accomplishing various obscure goals throughout the game and attaining the highest possible mental score, the player can unlock a different door in the hospital, leading down to the basement.

There, the nameless man must avoid legless versions of the girl in the blue dress, as they chase him through a hallway that becomes increasingly organic.

By completing a series of specific tasks and also attaining the white ending on the previous playthrough, giving a particular item to the first NPC the player meets will unlock a "joke" ending where the nameless man decides to simply dance his troubles away at the NPCs party instead of completing the game's tasks again.