Loomis is an unincorporated community and census-designated place (CDP) in Isabella County in the U.S. state of Michigan.

The community was first settled as early as 1871 by Erastus Loomis, George Wise, and E. F. Gould, who built a sawmill and a general store.

In 1877, Loomis recorded a population of around 350 and included several sawmills, general stores, churches, and two hotels.

With the expansion of U.S. Route 10 in the early 1960s, the highway bypassed Loomis to the north, which prevented any direct traffic to the dwindling community.

[7] The Loomis post office is no longer in operation, and the community is served by the Clare 48617 ZIP Code.