Unlike previous Looney Tunes-related shows, Loonatics Unleashed has a darker tone and takes place in a post-apocalyptic setting, following multiple minor story arcs.

After Loonatics Unleashed ended, the franchise would go on hiatus until the release of The Looney Tunes Show on Cartoon Network, four years later.

It is later revealed that Zadavia is in fact an alien and had used her powers to knock the meteor slightly off-course, preventing the total destruction of the planet.

In the season's finale, the Loonatics are temporarily joined by Sylth Vester and Optimatus is replaced by Deuce as the series arch-villain.

Animation, Sander Schwartz, who responded favorably to the pitch, and after showing the concept to a focus group of kids was given a formal production commitment.

[8] David Janollari, then President of Kids' WB expressed enthusiasm for the series and referred to it as "a great way to take the classic Looney Tunes franchise that has been huge with audiences for decades and bring it into the new millennium".

[7] In September 2006, The CW presented its lineup for the 2006–07 Saturday Morning schedule with Loonatics Unleashed returning for a second season, with the press release describing the show as a "breakout hit".

Joly Herman of Common Sense Media gave the show two stars out of five, saying that the jokes are "no longer very funny" and the characters have "become little more than filler material.