It connects several suburbs of Phoenix, including Tolleson, Glendale, Peoria, Scottsdale, Mesa, Tempe, and Chandler.

From that point, the route heads north entering Phoenix then Glendale, passing State Farm Stadium and Desert Diamond Arena.

East of this junction, Loop 101 curves south through Scottsdale on the Pima Road alignment.

Loop 101 then becomes the Price Freeway and continues south, passing Arizona State University to the east.

The resulting alignment kept all four corners of each interchange on tribal land, allowing the community to control and benefit from development.

[11] The Maryland Avenue HOV interchange in Glendale began construction in October 2013 and was completed in March 2014.

[12] In August 2014, construction began to add a fourth general-purpose lane in each direction for the 11-mile segment from Shea Boulevard to Loop 202 in Scottsdale.

[15] In February 2019, construction began to add a fourth general-purpose lane in each direction for the 13-mile segment from I-17 to Pima Road in Scottsdale and northeast Phoenix.

[16] In May 2019, construction began to add a fourth general-purpose lane in each direction for the 6.4-mile segment from Baseline Road to Loop 202 (Santan Freeway) in the East Valley.

[17] Construction began in January 2024 to add a fourth general-purpose lane in each direction for the 4.5-mile segment from Shea Boulevard to Princess Drive/Pima Road.

[18] Construction began in September 2024 to add a fourth general-purpose lane in each direction for the six-mile segment from 75th Avenue to I-17 in the northwest valley.