[6][7] Loose anagen syndrome is primarily described in fair-haired children who have easily dislodgeable hair.

[3] Each year there are approximately 2 to 2.5 cases per million people with loose anagen hair syndrome.

[10] The abnormalities caused by the inner root sheath creates disruption in the support and anchoring of the anagen hairs.

In the Huxley cells of the inner root sheath of abnormal anagen hairs, there is the formation of vacuoles and the build-up of fluid which is not usually seen.

Some patients visit a dermatologist for diagnosis and to distinguish between loose anagen hair syndrome and other conditions that it can be misdiagnosed for.

The patient will be diagnosed with loose anagen syndrome if great amounts of hair is detached from the head.

[2][6] The electron microscopy scanned image of the inner root sheath of a loose anagen hair would exhibit ultrastructural changes.

These changes in texture limits the ability for adjacent loose anagen hairs to rest flat on the scalp.

Loose anagen syndrome type A is when the hair of the patient appears to be fine and thinly distributed.

Patients with type A loose anagen syndrome experience a decrease in the density of their hairs.

[2] Patients with loose anagen syndrome may experience the thinning of their hair which is also a factor of alopecia areata.

[3] Loose anagen syndrome usually does not need treatment as this hair condition tends to improve with age and is self-limited.

[10] Many patients affected by loose anagen hair syndrome encounter spontaneous recovery by adulthood.

[7] The thickness and length of the hair of loose anagen syndrome patients have a tendency to improve and becomes more enhanced, especially post puberty.

[7] Paediatricians, paediatric nurse practitioners and physician assistances are usually the first people to detect this hair condition in children.

[4] From this, there is intensified DNA synthesis occurring in both follicular keratinocytes and non-follicular, as well as an increase in cell multiplication.

7 in 11 loose anagen hair syndrome patients find visible improvement after using minoxidil lotion.

[10] Treatment involving the maintenance of nutrients within the patient and biotin have not made any noted impacts to the improvement of loose anagen hair syndrome.

[7] For children, changes to their lifestyle and daily routine are altered and improved to reduce trauma to hair.

[3] The name ‘loose anagen syndrome’ was first adapted in 1989 by Price, Gummer, Hamm and Traupe in American literature.

[3] The genetic aspects and potential mechanisms for the cause of loose anagen syndrome was first discovered in 1992 by Baden, Kvedar and Magro.