Lope García de Castro (1516 - 8 January 1576) was a Spanish colonial administrator, member of the Council of the Indies and of the Audiencias of Panama and Lima.

In February 1564, Peruvian Viceroy Diego López de Zúñiga y Velasco died suddenly or was killed.

García de Castro was sent from Panama to take over the positions of governor, captain general, and president of the Audiencia.

Viceroy García de Castro decided to send a naval expedition to the west to investigate whether these islands were real.

On August 21, 1565, King Philip created a royal mint in Lima, at the urging of a previous viceroy, Diego López de Zúñiga y Velasco, but it was in existence only briefly.