Lopezville is a census-designated place (CDP) in Hidalgo County, Texas, United States.

It is named for Francisco Solano López, a former president of Paraguay, a descendant of whom founded his namesake trailer park.

[5] According to the United States Census Bureau, the CDP has a total area of 1.8 square miles (4.7 km2), all land.

6.3% of all households were made up of individuals, and 3.0% had someone living alone who was 65 years of age or older.

[23] Zoned ECISD elementary schools serving sections of Lopezville include De Escandon and Ramirez (grades PK-5).

[26] Robert Vela High School included ECISD parts formerly in the CDP.

All of Hidalgo County is in the service area of South Texas College.