Murillo, previously recorded as Nurillo, is a census-designated place (CDP) in Hidalgo County, Texas, United States.

[4] It is bordered to the west by Edinburg, the county seat, to the southwest by Lopezville, to the south by San Juan, and to the north by Cesar Chavez.

According to the United States Census Bureau, the Murillo CDP has a total area of 6.9 square miles (18.0 km2), all land.

Murillo is served by the Edinburg Consolidated Independent School District.

[25][26] Zoned elementary schools serving sections of Murillo include Betts, Cano-Conzalez, De Escandon, Esparza, Gorena, Lyndon B. Johnson, Ramirez, and Travis (grades PK-5) [27] Almost all of Murillo is zoned to Barrientes Middle School, with a small segment zoned to South Middle School.

All of Hidalgo County is in the service area of South Texas College.