Lord Melville was launched at Quebec in 1807.

[3] Lord Melville, Brown, master, was sailing from Saint Vincent to Glasgow when a fire and explosion destroyed her on 1 April 1809 in the Atlantic Ocean at 55°07′N 26°36′W / 55.117°N 26.600°W / 55.117; -26.600.

[5][6] The boatswain had gone to the spirits room with a lighted candle that ignited the fumes and started the fire.

The remaining 26 people on board took to her boats and were able to leave before she blew up.

[1] Register of Shipping for 1809 carried the annotation "Burnt" by her name.