The gameplay is very close to that of the Monster Hunter, God Eater, and Phantasy Star Portable series, featuring cinematic kills and mini-games.

Lord of Arcana takes place in a world called Horodyn, named after the land's first king.

Somewhere in Horodyn lies an ancient stone known only as "Arcana", which apparently holds great magical power.

As well as humans, the world is home to many great and powerful monsters and beasts, which are fought by warriors known as Slayers who seek Arcana.

Hitoshi Sakimoto served as the game's sound producer, with the score being composed by Nobuo Uematsu, Kenichiro Fukui, and Satoshi Henmi.