He began developing an interest in music beginning in elementary school, when he taught himself to play the piano and electronic organ and participated in some brass and rock bands.

[3][5] After Revolter, Sakimoto's music and synthesizer driver earned him immediate recognition in the industry, resulting in him being asked to score several PC-9801 and Mega Drive games such as Starship Rendezvous and Gauntlet IV, as well as use his driver both in the scores he wrote and for other games.

[1] Between 1990 and 1992, Sakimoto worked on over 20 different video games for several different companies such as Toshiba EMI, Artec, and Data East.

[1] Sakimoto's first encounter with mainstream success in Japan came about in 1993 when he composed Ogre Battle: March of the Black Queen.

The game was directed by Yasumi Matsuno, and since the release of the title, he has chosen Sakimoto as a regular for his development team at Quest and later Square.

Sakimoto also worked on 14 other titles that year, including Shin Megami Tensei and Alien vs.

[7] After leaving in 2000 he became freelance and went on to compose Breath of Fire V and Tactics Ogre: The Knight of Lodis for Capcom and Quest respectively.

Sakimoto says that he left Square to found the company because he wanted more freedom in choosing his projects.

The company expanded in the mid-2000s with the addition of Mitsuhiro Kaneda, Kimihiro Abe, Noriyuki Kamikura, Yoshimi Kudo, and Azusa Chiba.

In April 2007, he appeared at Eminence's A Night in Fantasia 2007: Symphonic Games Edition, which featured three of his compositions.

[16] Sakimoto and Mitsuda collaborated with Eminence in July the same year to create Destiny: Reunion, a concert held exclusively in Japan.

[19] Sakimoto composes his music by playing the pieces "briefly on the piano", and then working on a computer for more detailed arrangements.