Upon their return to Genoa, it is also probable he assisted in the restoration of Andrea Ansaldo's dome in the Basilica della Santissima Annunziata del Vastato.
From 1720 to 1722, Lorenzo painted an altar piece, Virgin and child with Saints Joseph, Ignatius Loyola and Francis Xavier, for the Church of Santi Ignazio e Francesco Saverio.
In the same period, to celebrate the canonization of Luigi Gonzaga and Stanislaus Kostka, he designed an ornamental structure erected in the Genoese church of the Gesú.
In 1736, he erected a series of elaborate structures, of which no trace remains today, in the Genoa Cathedral to celebrate the canonization of Catherine Fieschi Adorno.
In the same year he collaborated with Giovanni Battista Natali on a series of frescoes in the gallery of the Palazzo Spinola, where the central medallion shows Venus and Bacchus with Cupid, all of which demonstrate his newly formed style.