Among Conca's pupils there were Pompeo Battoni, Andrea Casali, Placido Campoli, Corrado Giaquinto, Gregorio Giusti,[4] Gaetano Lapis, Salvatore Monosilio, Litterio Paladini,[5] Francesco Preziao, Rosalba Maria Salvioni, Gasparo Serenari, Agostino Masucci,[6] Domenico Giomi,[7] and the Bavarian religious painter Franz Georg Hermann.
Sebastiano's brother, Giovanni Conca (died in 1764), painted the main altarpiece of the Madonna of the Rosary and St Dominic for the church of San Domenico, Urbino.
He worked for a period of time for the Savoy family in Turin on the Oratory of San Filippo and Santa Teresa, in the Venaria (1721–1725), for Basilica di Superga (1726), and Royal Palace (1733).
He painted the frescoes of Probatica (Pool of Siloam), in the Ospedale di Santa Maria della Scala (hospital) of Siena.
Among the works that reflect his late-Baroque style there are paintings such as The Vision of Aeneas in the Elysian Fields (c. 1735/1740); the scene is crowded with mythologic and classical figures, adrift in academic quotation, and enveloped by a world of overwrought with allegory.