Ottoni was born in Rome in 1658 and spent the majority of his life in the city.
Ottoni benefitted greatly from his Catholic contemporaries; enthusiastic patrons of the arts.
He also sculpted two white marble putti which are part of the monument of Christina, Queen of Sweden in St. Peter's Basilica.
Ottoni was elected in 1691 to the Accademia di San Luca in Rome and a short time later to the Congregazione dei Virtuosi al Pantheon (Assembly of Illustrious Artists), Rome's two most prestigious artists' organizations.
A bust of Cardinal Stefano Agostini by Lorenzo Ottoni is in the Forlì Pinacoteca Civica.