He was the founder of the Fascio dei lavoratori (Workers League) in his hometown Santo Stefano Quisquina, editor of the newspaper La Plebe and member of the Comitato della Federazione Regionale Socialista.

[1] He set up the Fascio in Santo Stefano Quisquina, which was dissolved after only a few months by the Government of Francesco Crispi, who violently repressed the movement in January 1894.

[1] In the early 20th century, with the resumption of agricultural strikes, Panepinto joined other peasant leaders like Bernardino Verro from Corleone and Nicola Alongi from Prizzi.

[2] Many townspeople from San Stefano Quisquina had emigrated to the United States, in particular to Tampa, Florida, where they worked in the cigar-making industry.

[4] But they also financially supported the setting up of the agricultural cooperative Unione agricola in their original hometown San Stefano Quisquina in 1902.

The group pledged a yearly stipend of 1,200 lire to the socialist section in their former hometown for work among the peasantry[3] In October 1920, the socialists of Santo Stefano Quisquina managed to conquer the city hall again, electing as mayor Giuseppe Cammarata, Panepinto's friend and collaborator, who continued the battle.