Upon their return to Genoa, it is also probable he assisted in the restoration of Andrea Ansaldo's dome in the Basilica della Santissima Annunziata del Vastato.
According to Jane Turner's The Dictionary of Art, his style was "...influenced by the graceful, elongated figures, spiraling movements and elaborate quadratura of his father.
From 1720 to 1722, Lorenzo painted an altar piece, Virgin and child with Saints Joseph, Ignatius Loyola and Francis Xavier, for the Church of Santi Ignazio e Francesco Saverio.
In the same period, to celebrate the canonization of Luigi Gonzaga and Stanislaus Kostka, he designed an ornamental structure erected in the Genoese church of the Gesú.
In the same year he collaborated with Giovanni Battista Natali on a series of frescoes in the gallery of the Palazzo Spinola, where the central medallion shows Venus and Bacchus with Cupid, all of which demonstrate his newly formed style.