[1] She graduated from Shaler Area High School in 1985, and studied English at Hood College.
[2] Lori Mizgorski ran for a seat on the Shaler Township board of commissioners in 2005,[3] missing it in a 562–584 vote.
[4] She was elected in 2009,[5][6] and from January 2011, concurrently served as Shaler Township representative to the Allegheny River Towns Enterprise Zone.
[11][12] To take office as a state legislator, Mizgorski was required to resign her township board position, in which she was replaced by her husband David.
[13] In April 2019, Mizgorski was appointed to the board of directors of the Port Authority of Allegheny County, by Mike Turzai, succeeding Robert Vescio.