Long before the Spanish settlers arrived to settle near the banks of the Los Angeles River, Native Americans were the only inhabitants.

Archeological surveys have found evidence of a substantial rancheria that existed in the mouth of Fern Dell Canyon in Griffith Park.

The name Gabrieleños was given to these people by the Spanish because of the Native Americans' association with the San Gabriel Mission.

Griffith never served in any branch of the U.S. armed forces, but he was given the honorary title of colonel by influential friends in the California National Guard.

[6]: 176–184, 258–269  [7] On May 8–9, 2007, about 800 acres (3.2 km2) of uninhabited terrain in Los Feliz and Griffith Park, including the famous Dante's View, were destroyed in a wildfire.

[8] After the fire, Los Angeles city officials pledged millions of dollars in aid to repair the damage.

[10][11] The neighborhood's boundaries (as used by Mapping L.A.) are the Griffith Park line between Fern Dell Drive and Riverside Drive on the north; the Los Angeles River on the east; Hyperion Avenue and Griffith Park Boulevard on the southeast; Fountain Avenue and Hollywood Boulevard on the south; and Western Avenue, Los Feliz Boulevard, and Fern Dell Drive on the west and northwest.

The 2000 U.S. census counted 35,238 residents in the 2.61-square-mile neighborhood—an average of 13,512 people per square mile, among the highest population densities in Los Angeles County.

Armenia (25.3%) and Mexico (9.4%) were the most common places of birth for the 44.5% of the residents who were born abroad, a high ratio compared to the rest of Los Angeles.

The Los Feliz Hills contain multimillion-dollar homes and have been known for the large share of their inhabitants being involved in creative pursuits.

In February 2014, a local shop called Dumb Starbucks was opened as a bit for the Comedy Central show Nathan for You in Los Feliz Village.

[39] Forty-two percent of Los Feliz residents aged 25 and older had earned a four-year degree in 2000, a high figure for the city.

[41] Buena Vista Street, the entrance to the California Adventure theme park at the Disneyland Resort, is partly modeled after Los Feliz in the 1920s and 1930s.

The Disney Buena Vista Street includes a retail location called Los Feliz Five and Dime.