The film centers on Hannah (Juno Temple), a shy songwriter, who discovers that her friend, respected record producer Theo Ross (Simon Pegg), has lapsed on his medication for schizophrenia.

"[16] Joey Magidson of Hollywood News also gave a positive review by stating "Simon Pegg and Juno Temple have never been better, exercising new acting muscles and causing you to re-evaluate what each is capable of.

"[17] Kristy Strouse of Film Inquiry gave another positive review by stating "Lost Transmissions really finds its identity in the softer moments between our two leads, as the heartbreak comes to the surface and they acknowledge their own (and each other's) struggles.

[19] Conversely, Alex Papaioannou of Popaxiom gave a mixed review by stating "Lost Transmissions takes the form of a bright spotlight that is necessary to expose harsh realities, and hopefully promote change.

"[20] Owen Gleiberman of Variety also gave a mixed review by stating "Lost Transmissions is a murky and unfocused journey, set in a Los Angeles that looks as sodden as London on an overcast day.