[1] The film aims to shine a light on the issue of homeless youth in the United States.

The film includes appearances by singers Jon Bon Jovi and Jewel,[3] actors Halle Berry, Rosario Dawson and Mike C. Manning (who is also a producer on the film)[3] and US Senator Patrick Leahy.

[2] Jewel also wrote a track for the film, "No More Tears", which was subsequently included on her 2022 album Freewheelin' Woman as a duet with Darius Rucker.

Lost in America is a continuation of Rotimi Rainwater's journey of shining the light on youth homelessness after directing the feature film Sugar.

[5] The film looks at the challenges faced by homeless youth such as sex trafficking, the failure of the foster care system and the lack of acceptance of LGBTQ kids.