Clark removed with his parents to Otsego County in 1796.
He was President of the Lockport Bank, and the local agent for the Albany Land Company, a group of investors who had bought large tracts of lands in Niagara and Orleans counties and in the northern parts of Genesee and Erie counties.
He was a member from Niagara County of the New York State Assembly in 1846.
Later he was President of the Niagara Falls International Bridge Company, the American company which built the first suspension bridge over the Niagara River together with the Canadian Niagara Falls Suspension Bridge Company headed by William Hamilton Merritt.
His son Lot C. Clark was District Attorney of Richmond County, New York from 1841 to 1849.