[4] If confirmed by the Senate, this would create a vacancy in her district, prompting a special election to fill the seat.

The district is primarily rural, but it also includes the cities of Ogdensburg, Glens Falls, Rome, and Plattsburgh.

It included all or parts of Albany, Fulton, Montgomery, Rensselaer, Saratoga, Schenectady, and Schoharie counties.

It contained the cities of Albany, Schenectady, Troy, Amsterdam, Cohoes, Watervliet, Gloversville, and Johnstown.

Up until 1980, the 21st district was located in Upper Manhattan (including parts of Harlem and Washington Heights), and The Bronx.