The festival grounds included a children's stage and village, an environmentally friendly vendor area, and a food court featuring restaurants from St. Louis neighborhoods.

[14] 2010 headliners included Broken Social Scene, She & Him, Built to Spill, The Airborne Toxic Event, Titus Andronicus, Fruit Bats, and Jeff Tweedy.

Artists performing: Saturday: Snoop Dogg, Cage the Elephant, Spoon, Huey Lewis & the News, Marian Hill, ZZ Ward, Rainbow Kitten Surprise, Hippo Campus, Middle Kids, Ron Gallo, Mvstermind, Jonny P, Chris Bandi, Mathias & the Pirates and Starwolf Sunday: Weezer, Run the Jewels, Nathaniel Rateliff & the Night Sweats, Lizzo, Lecrae, Robert Randolph & the Family Band, Houndmouth, The Record Company, Mondo Cozmo, Noname, Future Thieves, Okey Dokey, Jack Grelle, Jess Nolan, 18andcounting, Beth Bombara Note: Harts was originally scheduled to play Sunday but dropped off and was replaced by Okey Dokey.

[4] Artists performing: Saturday: Chris Stapleton, Band of Horses, Big Gigantic, St. Lucia, Preservation Hall Jazz Band, Charles Bradley and his Extraordinaries, Frightened Rabbit, The Heavy, Foxing, Caveman, Chicano Batman, Diarrhea Planet, The Quaker City Night Hawks, Twin Limb, JMR, Illphonics, Bruiser Queen, The Sleepy Rubies Sunday: LCD Soundsystem, Lauryn Hill, The Kills, Buddy Guy, Shakey Graves, Vince Staples, Greensky Bluegrass, Anderson .Paak & The Free Nationals, Wild Belle, Twin Peaks, Judah and the Lion, Rayland Baxter, Mothers, NAWAS, Bonnie Bishop, Aaron Kamm & The One Drops, Karate Bikini, John Hardy.

Saturday: Hozier, Ludacris, Brandon Flowers, Nate Ruess, Blue October, Albert Hammond Jr., Nico & Vinz, Robert DeLong, Milo Greene, Knox Hamilton, Jessica Hernandez & the Deltas, Colony House, Brave Baby, The Black Cadillacs, Coin, Clockwork, KOA Sunday: The Avett Brothers, Young the Giant, Billy Idol, Umphrey's McGee, Lord Huron, JJ Grey & Mofro, Pokey Lafarge, Misterwives, Delta Rae, Strand of Oaks, The Suffers, Walking Shapes, All Them Witches, The Bros. Landreth, Hembree, American Wrestlers, Earl Burrows The 2014 LouFest Music Festival was held on September 6–7 with a lineup that included the following: Saturday: Arctic Monkeys, Cake, The 1975, Future Islands, Yo La Tengo, Washed Out, RAC, Blackberry Smoke, Delta Spirit, San Fermin, Those Darlins, Falls, Skaters, Roadkill Ghost Choir, Black Pistol Fire, Alanna Royale, Kins, The Jane Shermans, Colin Lake, Big Brother Thunder and the Master Blasters Sunday: OutKast, Grouplove, Matt and Kim, Portugal.

The Man, Trombone Shorty and Orleans Avenue, Cherub, Vintage Trouble, Lettuce, Moon Taxi, Empires, Young & Sick, The Districts, Kopecky Family Band, Glass Animals, AJR, UME, Old Salt Union, Marc Scibilia, Dylan McDonald & the Avians, Pretty Little Empire Note: Kelis and Holychild were originally scheduled to perform but were later replaced by Yo La Tengo and UME The 2013 LouFest Music Festival was held on September 7–8.

Saturday, September 7: Wilco, Jim James, The National, Toro y Moi, Fitz and the Tantrums, Ra Ra Riot, Trampled by Turtles, Robert DeLong, J Roddy Walston and the Business, Jukebox the Ghost, Wild Belle, Desert Noises, Space Capone, Modoc, Kentucky Knife Fight Sunday, September 8: The Killers, Edward Sharpe and the Magnetic Zeros, Alabama Shakes, Icona Pop, Local Natives, Walk the Moon, Court Yard Hounds, Twin Shadow, Youngblood Hawke, The Mowgli's, Brick + Mortar, Wild Cub, Tef Poe, Andrea Davidson, The Lonely Biscuits The 2012 LouFest Music Festival was held on August 25–26.

[22] Saturday, August 25: Girl Talk, Dinosaur Jr., Phantogram, Son Volt, Little Barrie, Cotton Mather, King Tuff, Sleepy Kitty Sunday, August 26: The Flaming Lips, Dr. Dog, Dawes, Wild Nothing, Cults, Someone Still Loves You Boris Yeltsin, Thee Satisfaction, Pernikoff Brothers Note: We Are Scientists were originally scheduled to play Sunday but were forced to drop off for health reasons and were replaced by Wild Nothing.

Sunday, August 29: She & Him, Jeff Tweedy, Alejandro Escovedo, Fruit Bats, Cory Chisel and The Wandering Sons, Gentleman Auction House, Carolina Chocolate Drops, Magnolia Summer, Kim Massie The festival offers free water refills and discourages the use of plastic bottles.