Louis Joseph Guisto (January 16, 1895 – October 15, 1989) was an American Major League Baseball first baseman who played for five seasons.

He played for the Cleveland Indians from 1916 to 1917 and from 1921 to 1923.

He managed in the minors from 1929–1931.

The baseball field at Saint Mary's College of California, where Guisto played, is named Louis Guisto Field.

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