Louis R. "Lou" Nickinello (born September 8, 1940 in East Boston) is an American businessman and politician who served in the Massachusetts House of Representatives from 1971 to 1983.

Nickinello was appointed Executive Director of the Massachusetts Port Authority by Governor Edward J.

He was fired two weeks later after three board members appointed by new governor Michael S. Dukakis voted in favor of dismissing him.

[1] He was later appointed by Dukakis to serve as Massachusetts' Deputy Secretary of Transportation for Special Projects.

[2] After leaving politics, Nickinello served as President of Ackerley Communications' (later AK Media) business in Massachusetts, a billboard company.