Louis-Antoine Dessaulles (1818 – August 4, 1895) was a Quebec seigneur, journalist and political figure.
In 1847, Dessaulles began writing articles for the newspaper L'Avenir; he supported Papineau, opposed the political power of the Roman Catholic Church in Canada East, opposed the union of Upper and Lower Canada and supported annexation with the United States.
Dessaulles was editor for the Montreal paper Le Pays in its early days during the 1850s and again in 1861.
In financial difficulties, Dessaulles was forced to sell his property in 1867 and, in 1875, he fled to the United States and then to Belgium.
His brother Georges-Casimir was also mayor of Saint-Hyacinthe and served in the Quebec legislative assembly and the Senate of Canada.