Louis Francis O'Keefe (June 12, 1895 – July 10, 1965) was an American attorney and politician who was a member of the Massachusetts House of Representatives and a city solicitor and city councilor in Peabody, Massachusetts.

[1] He served in the United States Navy during World War I.

[1] He was defeated for reelection in 1950 and was appointed to the newly formed department of mental health board of appeals by Governor Paul A. Dever shortly after leaving office.

[3] He resigned on December 2, 1952, amid a Massachusetts Senate investigation into allegations that O'Keefe and board chair Kathleen Ryan Dacey had collected pay for meetings that were never held.

[4] O'Keefe died on July 10, 1965, at Quigley Memorial Hospital in Chelsea, Massachusetts.