In 1960 he began dancing professionally with José Limón, and also appeared with Flower Hujer, Alvin Ailey and Donald McKayle.

His farewell performance was with Luciana Savignano at La Scala Opera House in Milan in The Eagle's Nest.

[5] He was one of the first choreographers to experiment with rock bands and other innovations on stage, and he was noted for works created for his Louis Falco Dance Company and for his choreography of the 1980 motion picture Fame.

After the explosive success of the film, he began a career in commercial choreography including music videos for a number of MTV artists.

Falco completed choreography for several films and commissioned dance works, some of which were never performed in the United States.