Louis Grech was one of the first pioneers in the setting up and formation of the national flag carrier Air Malta under a Labour Government in 1973.

The Group had interests in Aviation and Tourism, employed around 2,500 workers, generated a turnover of approximately €293.5m, and was responsible for around 5.3% of Government revenue and 5.5% equivalent jobs in the country.

On 27 December 2012 he was elected as the Deputy Leader for Parliamentary Affairs of the Labour Party, replacing Angelo Farrugia.

Following the Labour Party's landslide win in the 2013 elections, Louis Grech was sworn in as the Deputy Prime Minister of Malta.

As a member of Joseph Muscat's first cabinet, he was given the post of Minister of European Affairs and Implementation of the Electoral Manifesto.