[3] His first experience in front of the camera was for Servicezeit, an evening magazine programme on WDR Fernsehen television network.

Along with Leon Seidel, who played the role of Huck Finn, he sang on the soundtrack of the film in the song, "Barfuß Gehen" ("Going Barefoot").

Beginning on 24 October 2013 Hofmann appeared in the comedy The Almost Perfect Man (German: Der fast perfekte Mann).

[8][9] His first international role as a German prisoner of war in the Danish-German co-production Land of Mine (Danish: Under sandet) earned him the Best Supporting Actor prize at Denmark's Bodil Awards in 2016.

[8] In 2016, Hofmann was cast as Jonas Kahnwald in Dark, a science fiction thriller released on Netflix on 1 December 2017.

He also appeared in Apple TV+ series Masters of the Air, produced by Tom Hanks and Steven Spielberg, which was released on 26 January 2024.