[citation needed] Dupuis lives southeast of Montreal, in an 1840 farmhouse located on 50 acres (20 ha) of land which he bought in 1996 and which he has restored and renovated.

In recent years, between television and film projects, he has been occupied with learning to sail; he owns a couple of sailboats, and he is custom-outfitting the larger aluminum-keeled vessel in preparation for extended ocean voyages.

[citation needed] Dupuis gained popularity in Quebec as Ovila Pronovost in the series Les Filles de Caleb (also known as Emilie) when it premiered on Radio-Canada (1990–91), and he co-starred as the journalist Michel Gagné in four seasons of Scoop (1992–95).

[3] In the United States, he also debuted on the big screen in such film roles as Becker in Screamers (1995) and as John Strauss in Bleeders (1996), also known as Hemoglobin (1997) in the UK.

[4] Among Dupuis' film performances are Yves, in Being at Home with Claude (1991; Cannes, Un Certain Regard 1992)--his first major screen role—directed by Jean Beaudin, adapted from a screenplay by Johanne Boisvert, based on the 1986 stage play by René-Daniel Dubois; and Kevin Barlow, in Manners of Dying (2004), the first feature film directed by Jeremy Peter Allen, adapted from his own screenplay based on the short story first published in the 1993 collection The Facts Behind the Helsinki Roccamatios and Other Stories by Yann Martel.

His performance as Alexandre Tourneur in Looking for Alexander (Mémoires affectives) (2004), directed by Francis Leclerc, who co-wrote the screenplay with Marcel Beaulieu, received awards.

Prior to its release, a "draft of the film" was screened as a courtesy by the producer, Laszlo Barna, to Paul Kagame, the President of Rwanda, and his cabinet, who found it emotionally very moving.

[20] On March 18, 2008, after a fourteen year absence, Dupuis returned to the stage for a limited run as Ian in a French translation of Blasted, the controversial first play by British playwright Sarah Kane (1971–1999).

[21] Jean-Marc Dalpé's French version, Blasté, directed by Brigitte Haentjens for her company Sybillines Inc., also featured Céline Bonnier and Paul Ahmarani.