This network was the first implementation of the pure datagram model, initially conceived and described by Donald Davies, subsequently named by Halvor Bothner-By, and seen by Louis Pouzin as his personal invention.

His work, and that of his colleagues Hubert Zimmerman and Gérard Le Lann, were acknowledged by Vinton Cerf as substantial contributions to the design of TCP/IP, the protocol suite used by the Internet.

Having participated in the design of the Compatible Time-Sharing System (CTSS) at MIT, Pouzin wrote a program for it called RUNCOM around 1963–64.

RUNCOM permitted the execution of commands contained within a folder and can be considered the ancestor of the command-line interface and shell scripts.

Working with Glenda Schroeder and Pat Crisman, he also described an early e-mail system called "MAIL" to allow users on the CTSS to send notifications to others about backups of files.

[17] In 2002 Pouzin, along with Jean-Louis Grangé, Jean-Pierre Henninot and Jean-François Morfin, participated in the creation of Eurolinc, which is a non-profit association that promotes multilingualism in domain names.