Louis Spencer Epes (January 12, 1882 – February 14, 1935) was an American lawyer, judge and politician.

He was educated in public schools in Nottoway and at Hoge Military Academy in Blackstone before he entered Hampden-Sydney College in 1898.

After graduating in 1901, he taught at Homer Military Academy in Oxford, North Carolina (1901-1903); West Kentucky College, Mayfield, Kentucky (1903-1904), and conducted a private collegiate preparatory school in Helena, Arkansas (1904-1906).

From 1911 to 1918, he was Mayor of Blackstone, resigning in 1918 to enter the United States Army, from which he was honorably discharged on December 5, 1918.

In 1919, he was elected to the Virginia State Senate from Nottoway, Lunenburg, Prince Edward, Cumberland and Amelia Counties and served two terms.