[3] Patrick Henry lived for some time in Louisa County on Roundabout Creek in 1764.

In 1765, Patrick Henry won his first election to represent Louisa County in the House of Burgesses.

[citation needed] The Virginia Central Railroad was completed through Louisa County in 1838–1840.

As a result, several significant cavalry actions took place in the county, particularly one fought at Trevilians in 1864.

The Twin Oaks Community is one of the country's oldest secular communes, established by its first eight members in 1967.

This was part of a national movement among numerous young people to "get back to the land" and live in more simple ways based in community.

In recent years the predominantly rural county has grown because of retirees' settling near Lake Anna, and because of its convenient location for commuters.

[5] The U.S. Geological Survey reported that a magnitude 5.8 earthquake hit Virginia on Tuesday, August 23, 2011, at 1:51 PM EST.

Although the county's 2008 population is only 31,000, it is one of the fastest-growing in Virginia, as people have moved near Lake Anna.