She is mostly known for adapting dramatic versions of Edward Bulwer-Lytton's Last Days of Pompeii (1835) and Ernest Maltravers (1838), and Robert Montgomery Bird's Nick of the Woods (1838), among others.
Louisa Medina's progressive inclinations concerning her education and self-reliance marks her as an indicator of the rise of First-Wave Feminism in America.
According to an interview she gave to the Spirit of the Times, her father was a Spanish shipping magnate whose business went bankrupt, leaving her in the charge of distant relatives.
Although the unknown relatives were indifferent to her education, Medina pursued "the bold, masculine studies usually adopted by the male rather than the female gender.
Theatrical manager and actor Lester Wallack wrote in his memoirs that Medina "was one of the most brilliant women I have ever met.
'[14] The Last Days of Pompeii included the spectacle of an erupting volcano on stage and Nick of the Woods had two characters ride a flaming canoe over a waterfall.
Shortly after this affair, Miller suddenly died of "brain fever," with many people suspecting Medina of poisoning her rival.