Louisa Virginia Harrison Holden (1830–1900) was an American political hostess who, as the wife of Governor William Woods Holden, twice-served as First Lady of North Carolina from May 29, 1865, to December 15, 1865, and from July 1, 1868, to March 22, 1871.

[1] She was the daughter of Robert Harrison, a prominent and wealthy resident of Raleigh.

[3] She served as first lady of North Carolina during her husband's two separate terms as governor, in 1865 and again from 1868 to 1871.

[4] Holden stood in place of her husband, who was incapacitated by poor health, in a lawsuit filed by newspaperman Josiah Turner.

The suit, which carried on from 1885 into the 1890s, was filed after Holden's husband had Turner arrested for allegedly assisting the Ku Klux Klan.