After being married she was, in accordance with contemporary custom in French nobility, able to have lovers, and she entered into a relationship with the Duke of Orléans, who had discontinued his affairs with Marie Louise Madeleine Victoire d'Argenton and Charlotte Desmares and was not able to enter into an affair with Marie-Madeleine de Parabère, whose mother and spouse refused to allow it.
She was the mistress of the Duke of Orléans between 1714 and 1716, when she was replaced as main favorite by the now widowed and motherless Marie-Madeleine de Parabère.
She successfully used her position to benefit the careers and acquire lucrative offices and pensions for her friends and relatives.
"[1] Sabran continued to be an intimate and influential friend of the Regent even after their relationship was discontinued, and was a known figure of his circle and participator of his court life during his entire regency.
On several occasions, she introduced the regent to prospective lovers and because of that, she was slandered as a pimp and a brothel madam.