Louise Ottilie Fresco (born 11 February 1952) is a Dutch scientist and writer known for her work on globally sustainable food production.

She is a professor at Wageningen University and a corresponding member of Belgium's Royal Academy of Overseas Sciences.

In May 2006, a British newspaper published Fresco's resignation letter as one of eight Assistant Directors-Generals of FAO.

In her letter, Fresco stated that "the Organization has been unable to adapt to a new era", that its "contribution and reputation have declined steadily" and "its leadership has not proposed bold options to overcome this crisis".

She is also columnist at NRC Handelsblad and chair of the selectionboard of the Johannes van Dam Prize.