[1] Her paternal grandparents were Louis I, Count of Montpensier and Gabriele de La Tour d'Auvergne.

He was killed in battle in May 1527 when he led the Imperial troops sent by Emperor Charles V against Pope Clement VII in what became the Sack of Rome.

The estates, however, had been sequestered by the French King Francis I (at the instigation of his mother, Louise of Savoy) when her brother Charles, Duke of Bourbon and Constable of France formed an alliance with Charles V. After the Duke's death at the siege of Rome, his fiefs were confiscated by the King.

[2] On 17 May 1530, she became the suo jure Duchess of Châtellerault, Countess of Forez, Baroness de Beaujeu, which had formed part of her brother Charles' inheritance, however the titles were revoked by the King in January 1532.

Louise married secondly on 21 March 1504, her cousin Louis de Bourbon, Prince of La Roche-sur-Yon.