After 1.3 miles (2.1 km), LA 88 passes through an interchange with US 90, the future route of I-49, which connects to Lafayette on the northwest and Morgan City on the southeast.

It ends immediately afterward at an intersection with LA 182 (West Old Spanish Trail) at a point known as Burke, 2.8 miles (4.5 km) northwest of New Iberia.

[2] In the original Louisiana Highway system in use between 1921 and 1955, the modern LA 88 made up the northern portion of State Route 448.

[3] La DOTD is currently involved in a program that aims to transfer about 5,000 miles (8,000 km) of state-owned roadways to local governments over the next several years.

[13] Under this plan of "right-sizing" the state highway system, the entire route of LA 88 is proposed for deletion as it does not meet a significant interurban travel function.