Due to Hurricane Katrina, the School of Dentistry was temporarily located in Baton Rouge but has since returned to its campus in New Orleans.

The LSU Health Sciences Center School of Medicine was founded in 1931 commissioned by Governor Huey Pierce Long, Jr.[3] It facility was originally located at 1542 Tulane Avenue, adjacent to the then-rebuilt Charity Hospital, which was completed in 1939.

That new school, upon examination, was found to have been supplied with every modern device or contrivance suggested and recommended by the national medical organizations.

Grassroots efforts to restore the Charity Hospital building failed when it was deemed by an arbitration panel to be more than 50% damaged.

In 2011, state and LSU officials broke ground on a $1.1 billion teaching hospital in the lower mid-city area of New Orleans.