Louisville is a city in northern Cass County, Nebraska, United States.

[3] Louisville was platted in about 1870 when the Burlington & Missouri River Railroad was extended to that point.

[5] A folk etymology maintains the name Louisville is derived from one Mr. Lois, the proprietor of a local gristmill.

The current mayor of Louisville is Rodney Petersen, a lifelong resident of the city.

[6] According to the United States Census Bureau, the city has a total area of 0.57 square miles (1.48 km2), all land.

33.5% of all households were made up of individuals, and 19.1% had someone living alone who was 65 years of age or older.

29.4% of all households were made up of individuals, and 11.9% had someone living alone who was 65 years of age or older.